NC1: Development of a novel Alzheimer’s therapy

POSTER (Image)


PRESENTER: Lorena P. Samentar

AUTHORS: Lorena P. Samentar, Pei-Pei Pan, Arnold Salazar, Adrienne S. Bugayong, Kayvon Etebar, Durin Uddin, and Nora B. Caberoy

MENTOR: Nora B. Caberoy


Alzheimer’s disease (AD) is a progressive neurodegenerative disease that has no cure. The pathological characteristics of Alzheimer’s include the deposition of amyloid beta plaques, formation of Tau tangles, and neuroinflammation. In AD, amyloid beta is primarily removed by phagocytosis through receptors whose activation results to inflammation. As part of our strategy to develop a cure for AD, we have created a hybrid protein. Our objective is to test whether the hybrid protein that we have generated can reduce amyloid beta load and prevent disease progression in a mouse model of AD. We administered our hybrid through daily injection in the abdomen. After 30 days, we sacrificed the mice and collected the brain and the other organs for biochemical and immunohistochemical analyses. Our results show that the hybrid protein crosses the blood brain barrier and colocalizes with the microglia and MerTK receptor in the brain. Treatment of the hybrid protein reduces Aβ burden in the brain, protects the nerve cells from dying, reduces the level of IL-6 pro-inflammatory cytokine, and is not toxic to the liver and kidneys of female 3xTg-AD mice.

One Reply to “NC1: Development of a novel Alzheimer’s therapy”

  1. Sakina Axelrod says:

    My husband first experienced confusion and loss of memory in March of 2000 while undergoing rehab for alcoholism. Being home seemed to help him until 2006 when he gradually began experiencing Alzheimer’s symptoms. He had four to five hours a day where he wants to get a “greyhound” to “go home.” Also, he thinks I am his sister and believes he has rented a car (he hasn’t driven in five to 10 years). His personal hygiene was in the tank — it was necessary for him to change two to three times a day. Without long-term insurance for his care, it was becoming stressful to care from him. this year our family doctor introduced and started him on Healthherbsclinic Alzheimer’s Disease Herbal Tincture, 6 months into treatment he improved dramatically. At the end of the full treatment course, the disease is totally under control. No case of Alzheimer’s, hallucination, forgetfulness, and other he’s strong again and able to go about daily activities. visit their official website, www. healthherbsclinic. com

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