EO1: Developmental Neurogenetics – Analysis of Multiple Mouse Strains Resulting in Neurodevelopmental Disorders

POSTER (Image):

POSTER PRESENTATION (Video):

PRESENTER: Aaron Cheng

AUTHORS: Aaron Cheng, Van Vo Ph.D., Edwin Oh Ph.D. 

MENTOR: Edwin Oh, Ph.D. 

ABSTRACT:

Neurodevelopmental disorders (NDDs) are a group of disorders classified by the abnormal development of the central nervous system (CNS). These disorders, though individually rare, are cumulatively common across the world. The field of neurogenetics has played a significant role in the understanding of these disorders due to the prevalence of certain reported copy number variants (CNVs) and single-gene mutations.In this study, we will utilize multiple Cre-mediated knockout mouse models to 1) model rare neurodevelopmental orders in a mammalian model and 2) analyze the molecular systems affecting brain development via genetic manipulations and immunohistochemistry. From the deeper analysis of these mutant strains, we are able to characterize multiple genes that play a pivotal role in brain development. More specifically, we are able to show many different cellular mechanisms that are important in the development of NDDs. With a better understanding of these cellular mechanisms, the potential of therapeutics such as novel drug discovery and the development of gene therapies can emerge.  

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